期刊
FOOD CHEMISTRY
卷 132, 期 4, 页码 1987-1995出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2011.12.037
关键词
Anti-tumour activity; Citrus pectin; Commercial pectic enzyme; Lactate dehydrogenase activity; Galactin-3; BALB/c mouse
资金
- Natl. Science Council of the Republic of China [NSC 98-2313-B-020-013-MY3]
Anti-tumour activity and membrane permeability of 1 kDa oligogalacturonide (PET-pectin), prepared from citrus pectin after 24 h hydrolysis, by commercial pectic enzyme produced by Aspergillus niger, on four human cell lines (HepG2, A549, Colo 205, and HEK293) and the uptake of oligogalacturonide by HEK293 cell and BALB/c mouse were investigated. PET-pectin causes a higher value of growth inhibition, lactate dehydrogenase release, and galactin-3 release in human cancer cells, as compared to the human normal HEK293 cell. There was a good correlation between growth inhibition of human cells and the uptake of rhodamine B-PET-pectin content by these cells. Additionally, almost no difference between growth inhibitions of human normal HEK293 cells cultivated with PET-pectin and pectin was found. Total pectin content in the blood of PET-pectin administrated mice increased to a maximum at 2 h after oral administration, while it did not increase and change in pectin administrated mice. Our findings suggested that citrus PET-pectin can be developed as a potential dietary supplement in plant origin for cancer prevention. (C) 2011 Elsevier Ltd. All rights reserved.
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