期刊
FOOD CHEMISTRY
卷 124, 期 2, 页码 437-443出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2010.06.049
关键词
Influenza A; Neuraminidase inhibitors; Oseltamivir resistance; Vitis amurensis; Oligostilbenes
资金
- Korean government (MOST) [M10642140004-06N4214-00410, RO1-2008-000-20253-0]
Recently, a novel H1N1 influenza A virus (H1N1/09 virus) was identified and considered a strong candidate for a novel influenza pandemic. As part of an ongoing anti-influenza screening programme on natural products, eight oligostilbenes were isolated as active principles from the methanol extract of Vitis amurensis. This manuscript reports the isolation, structural elucidation, and anti-viral activities of eight compounds on various neuraminidases from influenza A/PR/8/34 (H1N1), novel swine-origin influenza A (H1N1), and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. The inhibition model of compounds 4, 6, and 7 which showed the strongest activity on the neuraminidases was examined. Detailed kinetic analysis indicated that they were all non-competitive. The synergistic effect of a combination of these non-competitive inhibitors with oseltamivir makes them a potential possibility for the control of influenza infections. (C) 2010 Elsevier Ltd. All rights reserved.
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