Antioxidation and antiglycation of polysaccharides from Misgurnus anguillicaudatus

Misgurnus anguillicaudatus is a fish widely inhabiting rivers, lakes, ponds, swamps and rice fields in China, Japan, Korea and other Asian countries. It is edible and can be used to treat xiao ke (namely diabetic) in traditional Chinese medicine. Polysaccharides from M. anguillicaudatus (MAPS) were extracted and separated into four parts which were named MAP I, MAP II MAP III and MAP IV, respectively. The percentage of polysaccharide in dry weight is about 3.06%. Hydroxyl radical and superoxide radical anion scavenging activities together with glycation inhibition of these polysaccharides were investigated. The results showed that all the MAPs had an inhibitory effect on oxidation and glycation and exhibited a dose-dependent response. Especially MAP IV displayed a stronger antioxidation effect than glucosamine and better antiglycation activities than aminoguanidine. As oxidation and glycation are relevant to diabetic complications, the result of this work suggests that MAPS may be effective in preventing and treating diabetic complications. (C) 2010 Elsevier Ltd. All rights reserved.