期刊
FOOD CHEMISTRY
卷 128, 期 1, 页码 152-157出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2011.03.011
关键词
Acai; Euterpe oleracea Mart.; Flavonoid; Antioxidant; Anti-inflammation
资金
- MonaVie LLC (South Jordan, UT)
Five flavonoids, (2S,3S)-dihyrokaempferol 3-O-beta-D-glucoside (1) and its isomer (2R,3R)-dihydrokaempferol 3-O-beta-D-glucoside (2), isovitexin (3), velutin (4) and 5,4'-dihydroxy-7,3',5'-trimethoxyflavone (5), were isolated from acai (Euterpe oleracea Mart.) pulp. The structures of these compounds were elucidated based upon spectroscopic and chemical analyses. To our knowledge, compounds 1, 2, 4 and 5 were identified from acai pulp for the first time. The in vitro antioxidant activities of these compounds were evaluated by the oxygen radial absorbance capacity (ORAC) assay. The ORAC values varied distinctly (4458.0-22404.5 mu mol Trolox equivalent (TE)/g) from 5,4'-dihydroxy-7,3',5'-trimethoxyflavone (5) to isovitexin (3) and were affected by the numbers/positions of hydroxyl groups, substitute groups, as well as stereo configuration. The anti-inflammatory effects of these compounds were screened by the secreted embryonic alkaline phosphatase (SEAP) reporter assay, which is designed to measure NF-kappa B activation. Velutin (4) was found to dose-dependently inhibit SEAP secretion in RAW-blue cells induced by LPS, with an IC50 value of 2.0 mu M. Velutin (4) also inhibited SEAP secretion induced by oxidised LDL, indicating potential athero-protective effects. (C) 2011 Elsevier Ltd. All rights reserved.
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