期刊
JOURNAL OF THE ROYAL SOCIETY INTERFACE
卷 12, 期 108, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsif.2015.0320
关键词
fibrous matrix; buckling; three-dimensional traction force; cell mechanics
资金
- National Science Foundation (Division of Materials Research) through the Center for the Science and Engineering of Materials at the California Institute of Technology [0520565]
- National Science Foundation [DMR-1206121]
- National Science Foundation Graduate Research Fellowship [DGE-1144469]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1206121] Funding Source: National Science Foundation
Biological cells sense and respond to mechanical forces, but how such a mechanosensing process takes place in a nonlinear inhomogeneous fibrous matrix remains unknown. We show that cells in a fibrous matrix induce deformation fields that propagate over a longer range than predicted by linear elasticity. Synthetic, linear elastic hydrogels used in many mechanotransduction studies fail to capture this effect. We develop a nonlinear microstructural finite-element model for a fibre network to simulate localized deformations induced by cells. The model captures measured cell-induced matrix displacements from experiments and identifies an important mechanism for long-range cell mechanosensing: loss of compression stiffness owing to micro, buckling of individual fibres. We show evidence that cells sense each other through the formation of localized intercellular bands of tensile deformations caused by this mechanism.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据