期刊
JOURNAL OF THE ROYAL SOCIETY INTERFACE
卷 12, 期 111, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsif.2015.0507
关键词
mesoporous diopside; biocomposite; mesoporous/macroporous scaffolds; degradability; osteogenesis
资金
- National Natural Science Foundation of China [51173041, 31271031]
- National Science and Technology Support Plan Projects [2012BAD32B01]
- International Cooperation Project of the Ministry of Science and Technology of China [2013DFB50280]
- Major International Joint Research Project between China and Korea [81461148033, 31311140253]
- Key Medical Programme of Science and Technology Development of Shanghai [12441902802]
Bioactive mesoporous diopside (m-DP) and poly(L-lactide) (PLLA) composite scaffolds with mesoporous/macroporous structure were prepared by the solution-casting and particulate-leaching method. The results demonstrated that the degradability and bioactivity of the mesoporous/macroporous scaffolds were significantly improved by incorporating m-DP into PLLA, and that the improvement was m-DP content-dependent. In addition, the scaffolds containing m-DP showed the ability to neutralize acidic degradation products and prevent the pH from dropping in the solution during the soaking period. Moreover, the scaffolds containing m-DP enhanced attachment, proliferation and alkaline phosphatase activity of MC3T3-E1 cells, which were also m-DP content-dependent. Furthermore, the histological and immunohistochemical analysis results showed that the scaffolds with m-DP significantly promoted new bone formation and improved the materials degraded in vivo, indicating goodbiocompatibility. The results suggested that the mesoporous/macroporous scaffolds of the m-DP/PLLA composite with osteogenesis had a potential for bone regeneration.
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