期刊
FOOD BIOPHYSICS
卷 7, 期 2, 页码 145-154出版社
SPRINGER
DOI: 10.1007/s11483-012-9252-5
关键词
Hydrogel particles; Biopolymer particles; Emulsions; Delivery systems; Transglutaminase; In vitro digestion
资金
- United States Department of Agriculture, CREES, NRI
- University of Massachusetts (CVIP)
- University of Massachusetts (Hatch)
The objective of this study was to determine the influence of encapsulation of protein-coated lipid droplets within biopolymer hydrogel microspheres on their digestibility by lipase. We therefore compared the in vitro lipid digestion of non-encapsulated (emulsions) and encapsulated (filled microspheres) casein-coated lipid droplets. Filled microspheres were fabricated from a phase separated mixture of pectin and sodium caseinate and emulsified oil to form an oil-in-water-in-water (O/W/W) emulsion. The microspheres were then acidified, cross-linked with transglutaminase, and washed to remove excess pectin. Filled hydrogel microspheres were stable to simulated mouth conditions but formed large flocs under simulated gastric conditions. The casein stabilized emulsion showed modest droplet flocculation under simulated mouth conditions and showed significant flocculation and coalescence under simulated gastric conditions. The structure of both microspheres and emulsions was completely destroyed following in vitro digestion. Digestion profiles revealed similar rates of lipid digestion for both microspheres and emulsions. Since in vitro digestion conditions simulate the small intestine, the region of the body where the majority of lipid digestion and absorption occurs, these results suggest that lipid droplets encapsulated within microspheres would be digested similarly to those in conventional emulsions. Based on these findings, filled hydrogel microspheres appear to be a suitable delivery system for lipophilic bioactives.
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