期刊
FOOD BIOPHYSICS
卷 6, 期 2, 页码 267-273出版社
SPRINGER
DOI: 10.1007/s11483-011-9211-6
关键词
Ibuprofen; Phase solubility; Cyclodextrins; Inclusion complex; Chiral discrimination
资金
- Provincia Autonoma di Trento (Italy)
The effects of chiral discrimination in inclusion complexes formed by native beta-cyclodextrin and its substituted form (namely methyl-beta-cyclodextrin) with racemate or pure enantiomers of the non-steroidal anti-inflammatory drug ibuprofen have been investigated in water. Stability constants and complexation efficiency have been determined for these host-guest systems with a 1: 1 molar ratio from phase solubility profiles, showing that in aqueous solution, methylated cyclodextrin is a better complex agent than native cyclodextrin, with more enhanced effects for the (R)-enantiomer. These results have been validated using NMR technique. In particular, (1)H NMR spectra in D(2)O show a splitting of the signals for the methyl group and the aromatic protons close to the asymmetric centre of the racemate ibuprofen included in cyclodextrin cavity.
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