期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 66, 期 -, 页码 107-112出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2014.01.011
关键词
Tobacco; Cytogenetic assessment; Biomarker; SCEs
According to the International Agency for Research on Cancer, smoking tobacco is a major cause of cancer in humans. It causes about half of all male cancer deaths and an ever increasing number of cancer deaths in females. The aim of this study was to establish whether cigarette smoking increases sister chromatid exchanges (SCEs) in peripheral blood lymphocytes in two Spanish population groups; light and heavy smokers. The mean number of High-Frequency Cells (HFCs) was determined and, the SCE distribution pattern among the chromosomes was analysed represented by a ratio described below. A local sample of 101 adult smokers (n = 48) and non-smokers (n = 53), aged from 18 to 49 years, was studied using SCE levels in peripheral lymphocytes. Heavy smoking (>= 10 cigarettes per day) increased significantly the SCE frequency and the HFC parameters. Neither age nor sex significantly influenced the frequencies in the groups studied. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.
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