期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 68, 期 -, 页码 218-225出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2014.03.022
关键词
Bee venom; Melittin; FAK; MMP; Cancer invasion
资金
- Next-Generation Biogreen 21 Program, Rural Development Administration, Republic of Korea [9009534022014]
- Basic Science Research Program through National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology (MEST) [2011-0021574]
- National Research Foundation of Korea [2011-0021574] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Bee venom is a natural compound produced by the honey bee (Apis mellifera), and has been reported as having the biological and pharmacological activities, including anti-bacterial, anti-viral and anti-inflammation. In the present study, the inhibitory effects of bee venom and its major peptide components on the tumor invasion were demonstrated. It was confirmed the inhibitory effects of bee venom, melittin, and apamin on the EGF-induced invasion of breast cancer cells. Transwell invasion and wound-healing assays showed that bee venom and melittin significantly inhibits the EGF-induced invasion and migration of breast cancer cells. Also, bee venom and melittin reduced the EGF-stimulated F-actin reorganization at the leading edge, but apamin did not affect. Particularly, melittin inhibited the EGF-induced MMP-9 expression via blocking the NF-kappa B and PI3K/Akt/mTOR pathway. In addition, melittin significantly suppressed the EGF-induced FAR phosphorylation through inhibition of mTOR/p70S6K/4E-BP1 pathway. These results suggest that inhibitory effects of melittin on breast cancer cell motility and migration may be related to the inhibition of mTOR pathway. (C) 2014 Elsevier Ltd. All rights reserved.
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