期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 74, 期 -, 页码 60-67出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2014.08.018
关键词
Adolescents; Arsenic methylation capability; HOMA-IR; Insulin resistance; Obesity
资金
- Taipei Medical University Hospital [99TMU-TMUH-02-3]
- National Science Council Taiwan [NSC 100-2314-B-038-026, NSC 101-2314-B-038-051-MY3) (1-3)]
The goal of the present study was to compare the arsenic methylation capacities in elementary school and junior high school students in an area of Taiwan with low arsenic exposure, and explore the influence of both arsenic methylation capacity and obesity on insulin resistance in these children and adolescents using the HOMA-IR index. We recruited 303 elementary school students and 319 junior high school students in Taipei City from September 2007 to November 2011. Concentrations of inorganic arsenic (arsenite + arsenate), monomethylarsonic acid (MMA(v)) and dimethylarsinic acid (DMA(v)) were determined by a high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Insulin resistance was determined by HOMA-IR Elementary school students had significantly lower inorganic arsenic percentage and a higher DMA(v) percentage than junior high school students. It seems that the former had better arsenic methylation capability than the latter. The HOMA-IR value was significantly and positively related to the sum of the urinary inorganic and methylated arsenic (TotalAs) concentrations and also the BMI Z score, with the regression coefficients (beta) being 0.058 (p < 0.001) and 0.001 (p = 0.027), respectively. The higher BMI values and higher TotalAs concentration were associated with higher HOMA-IR values in children and adolescents in Taiwan. (C) 2014 Elsevier Ltd. All rights reserved.
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