期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 64, 期 -, 页码 210-216出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2013.11.033
关键词
Allantoin; Neurogenesis; Learning and memory; Nelumbo nucifera; Hippocampus
资金
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2012R1A2A2A02012332]
- National Research Foundation of Korea [2012R1A2A2A02012332] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Allantoin is contained in Nelumbo nucifera (lotus) and a well-known cosmetic ingredient reported to have anti-oxidative and anti-inflammatory activities. In the present study, we investigated whether allantoin affects cognitive function in mice. The subchronic administration of allantoin (1, 3 or 10 mg/kg, for 7 days) significantly increased the latency time measured during the passive avoidance task in scopolamine-induced cholinergic blockade and normal naive mice. Allantoin treatment (3 or 10 mg/kg, for 7 days) also increased the expression levels of phosphorylated phosphatidylinositide 3-kinase (PI3K), phosphorylated protein kinase B (Akt) and phosphorylated glycogen synthase kinase-3 beta (GSK-3 beta). Doublecortin and 5-bromo-2-deoxyuridine immunostaining revealed that allantoin significantly increased the neuronal cell proliferation of immature neurons in the hippocampal dentate gyrus region. In conclusion, allantoin has memory-enhancing effects, and these effects may be partly mediated by the Pl3K-Akt-GSK-3 beta signal pathway. These findings suggest that allantoin has therapeutic potential for the cognitive dysfunctions observed in Alzheimer's disease. (C) 2013 Elsevier Ltd. All rights reserved.
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