期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 57, 期 -, 页码 91-98出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2013.03.012
关键词
Jacaranda caroba (Vell.) A. DC; HPLC DAD ESI/MS; Dicaffeoyl acid derivatives; Flavonoids; Antidepressant activity; Antiradical activity
资金
- Fundacao para a Ciencia e a Tecnologia (FCT) [Est-C/EQB/LA0006/2011, SFRH/BPD/63922/2009]
- Consolider Ingenio 2010 Project [CSD2007-00063 FUN-C-FOOD]
- Grupo de Excelencia de la Region de Murcia [04486/GERM/06]
Diseases affecting the central nervous system are spread throughout the world. As so, more efficient and safe neuroprotective drugs are required. The present study describes, for the first time, the phenolic composition and bioactivity of Jacaranda caroba (Vell.) A. DC, a species whose infusion is consumed as traditional medicine. The HPLC-DAD-ESI/MSn analysis revealed the presence of four dicaffeoyl acid derivatives and nine flavonoids, comprising quercetin, kaempferol and isorhamnetin derivatives. Twelve compounds are described for the first time in Jacaranda genus. Although isorhamnetin-3-O-rhmanoside-7,4'-di-O-glucoside and quercetin-3-O-(2-pentosyl)hexoside are the main metabolites in both aqueous and hydromethanolic extracts, qualitative and quantitative differences were found between them. Aqueous extract is richer in dicaffeoyl acid derivatives. Both extracts proved to be strong radicals' scavengers and effective monoamine-oxidase A inhibitors, but showed weak protection against cholinesterases' activity. The results highlight the value off. caroba as a source of health-promoting antioxidants and antidepressant compounds. (C) 2013 Elsevier Ltd. All rights reserved.
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