期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 50, 期 7, 页码 2473-2480出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2011.10.047
关键词
Tea flower; Polysaccharide; Characterization; Antioxidant activity; Hepatoprotective activity; Antitumor activity
资金
- Fundamental Research Funds for the Central Universities [KYZ201002]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
In the present study, the crude polysaccharides from the flowers of tea plant (Camellia sinensis) (TFPS) were prepared with hot water and further fractionated on a DEAE-52 cellulose chromatography to afford three purified fractions of TFPS-1, TFPS-2 and TFPS-3. Then, their preliminary structures, antioxidant and antitumor activities in vitro and hepatoprotective activity in vivo were investigated. Compared with TFPS-2 and TFPS-3, TFPS-1 had relative higher content of sulfate and relative complicated monosaccharide composition. In addition, TFPS-1 and TFPS-3 showed relative stronger antioxidant activity and inhibitory activity on the growth of human gastric cancer BGC-823 cells. For hepatoprotective activity in vivo, we demonstrated that crude TFPS significantly prevented the increase of serum alanine aminotransferase and aspartate aminotransferase levels, reduced the formation of malondialdehyde and enhanced the activities of superoxide dismutase and glutathione peroxidase in carbon tetrachloride-induced liver injury mice. The results suggested that TFPS should be a potent natural polymer with antioxidant, hepatoprotective and antitumor activities. (c) 2011 Elsevier Ltd. All rights reserved.
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