期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 50, 期 11, 页码 4042-4050出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2012.08.037
关键词
alpha-Mangostin; gamma-Mangostin; Garcinia mangostana; Asthma
资金
- KRIBB Research Initiative Program [KGM2241012]
- GRRC program of Gyeonggi province of the Republic of Korea [GRRC DONGGUK2012-B02]
- National Research Council of Science & Technology (NST), Republic of Korea [KGM1221211] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
alpha- and gamma-Mangostin, which are the major xanthones purified from a Mangosteen. Carcinia mangostana Linn., exhibit a wide range of anticancer, antioxidant, and anti-inflammatory activities. Here, we assessed their therapeutic effects in a mouse model of ovalbumin (OVA)-induced allergic asthma. Animals were treated with alpha- and gamma-mangostins orally for 3 days at doses of 10 and 30 mg/kg daily, 1 h before the OVA challenge. Administration of alpha- and gamma-mangostins significantly reduced the major pathophysiological features of allergic asthma, including inflammatory cell recruitment into the airway, airway hyper-responsiveness (AHR), and increased levels of Th2 cytokines. In addition, alpha- and gamma-mangostins attenuated the increases in phosphoinositide 3-kinase (PI3K) activity, phosphorylation of Akt, and NF-kappa B in nuclear protein extracts after OVA challenge. In conclusion, alpha- and gamma-mangostin may have therapeutic potential for the treatment of allergic asthma. (C) 2012 Elsevier Ltd. All rights reserved.
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