期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 50, 期 12, 页码 4310-4315出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2012.07.070
关键词
Ochratoxin A; Lactobacilli; Cytokines; Apoptosis; Membrane rafts
资金
- CONICET
- Agencia Nacional de Promocion Cientifica y Tecnologica, Argentina
- CIUNT-UNT
Ochratoxin A (OTA) is a widespread mycotoxin contaminating several food products which causes detrimental health effects. The ability of Lactobacillus reuteri CRL 1098 and Lactobacillus acidophilus CRL 1014 to prevent OTA effects on TNF-alpha and IL-10 production and apoptosis induction in human peripheral blood mononuclear cells (PBMC) was investigated. Membrane rafts participation in these responses was also evaluated. L reuteri reduced by 29% the OTA inhibition of TNF-alpha production whereas L acidophilus increased 8 times the TNF-alpha production by OTA treated-PBMC. Also, both bacteria reversed apoptosis induced by OTA by 32%. However, neither of the bacteria reversed the OTA inhibition on IL-10 production. On the other hand, the lactobacilli were less effective to reverse OTA effects on disrupted-rafts PBMC. This study shows that two lactobacilli strains can reduce some negative OTA effects, being membrane rafts integrity necessary to obtain better results. Also, the results highlight the potential capacity of some lactobacilli strains usually included in natural dietary components in milk-derived products and cereals feed, to reduce OTA toxicity once ingested by humans or animals. (C) 2012 Elsevier Ltd. All rights reserved.
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