期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 50, 期 9, 页码 3256-3263出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2012.06.052
关键词
Stacked genetically-modified; High oleic acid soybean; Rat; Subchronic
资金
- Genetically Modified Organisms Breeding Major Projects of PR China [2011ZX08011-005, 2011ZX08011-006, 2012ZX08011003]
The genetically-modified (GM) soybean 3empty set5423 x 40-3-2 expresses siRNA for the fatty acid desaturase-2 enzyme which results in higher concentrations of oleic acid (18:1) relative to linoleic acid (18:2) compared with non-GM soybeans. It also expresses the CP4 EPSPS protein for tolerance to glyphosate. In this study, three different dietary concentrations (7.5%, 15% and 30% wt/wt) of 3empty set5423 x 40-3-2 or non-GM soybeans were fed to Sprague-Dawley rats for 90 days during which in-life nutritional and growth performance variables were evaluated followed by analysis of standard clinical chemistry, hematology and organ variables. Compared with rats fed the non-GM control diet, some statistically significant differences were observed in rats fed the 3empty set5423 x 40-3-2 diet. However the differences were not considered treatment-related and commonly fell within the normal ranges of the control group consuming the commercial diet. These results demonstrated that the GM soybean 3empty set5423 x 40-3-2 is as safe as non-GM soybeans. (C) 2012 Elsevier Ltd. All rights reserved.
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