期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 49, 期 12, 页码 3018-3024出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2011.09.038
关键词
Yuzu; Hesperidin; Naringin; Platelet cytotoxicity; Platelet aggregation; Bleeding time
资金
- Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea [308013-3]
- Cooperative Research Program for Agriculture Science & Technology Development Rural Development Administration, Republic of Korea [PJ006986]
- Korea Food and Drug Administration [2009-2011]
- Rural Development Administration (RDA), Republic of Korea [PJ00698620111135303] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In this study, we investigated whether the methanolic extract of yuzu (yuzu ME) and its components hesperidin and naringin, have anti-platelet activities. Yuzu ME and hesperidin inhibited collagen-, arachidonic acid (AA)-, ADP- and thrombin-induced rat platelet aggregation in vitro and ex vivo. Naringin also inhibited platelet aggregation induced by collagen, AA, or thrombin, but not aggregation induced by ADP. The oral administration of yuzu ME or hesperidin prolonged mouse tail vein bleeding time in a dose-dependent manner in vivo. These results suggest that yuzu ME and hesperidin have anti-platelet activity, and that intake of yuzu, which includes various flavonoids such as hesperidin, may be beneficial for individuals at high risk of cardiovascular diseases. (C) 2011 Elsevier Ltd. All rights reserved.
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