期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 48, 期 2, 页码 626-632出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2009.11.043
关键词
Senescence; Mitochondria; Alzheimer's disease; Oxidative stress; Neuroprotection
资金
- Indian Council of Medical Research (ICMR), New Delhi
- University Institute of Pharmaceutical Sciences
Role of mitochondrial dysfunction and oxidative stress has been well documented in aging and related disorders such as Alzheimer's disease. Bioflavonoids have been reported to have a therapeutic potential against several age related processes Bioflavonoids are being used as a neuroprotectants in the treatment of various neurological disorders including aging. Therefore, present study has been conducted in order to explore the possible role of naringin against D-galactose induced cognitive dysfunction. oxidative damage and mitochondrial dysfunction in mice Chronic administration Of D-galactose (100 mg/kg) for 6 weeks significantly impaired cognitive performance (both in Morris water maze and elevated plus maze), locomotor activity, oxidative defense and mitochondrial complex (I, II and III) enzymes activities as compared to sham group. Six weeks naringin (40 and 80 mg/kg) treatment significantly improved cognitive performance, oxidative defense and restored mitochondria complex enzyme activities as compared to control (D-galactose). Naringin treatment significantly attenuated acetylcholine esterase activity in D-galactose treated mice In conclusion, present study highlights the potential role of naringin against D-galactose induced cognitive impairment, biochemical and mitochondrial dysfunction in mice Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
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