期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 47, 期 2, 页码 293-297出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2008.11.012
关键词
Red alga; Laurencia undulata; Asthma; Cytokines; Airway hyperresponsiveness
资金
- Korean government (MOST) [R13-2007-023-00000-0]
- Korea Institute of Science & Technology Evaluation and Planning (KISTEP)
- Ministry of Science & Technology (MOST), Korean government, through its National Nuclear Technology Program
The aim of the present work is focused on protective effects of an edible red alga, Laurencia undulata ethanolic (EtOH) extracts (LU) containing a large amount of polyphenols against OVA-induced murine allergic airway reactions using in vivo histological and cytokine assay. Mice sensitized and challenged with ovalbumin (OVA) showed typical asthmatic reactions as follows: an increase in the number of eosinophil in bronchoalveolar lavage fluid; a marked influx of inflammatory cells into the lung around blood vessels and airways, and airway luminal narrowing: the development of airway hyperresponsiveness; the detection of TNF-alpha and Th2 cytokines, such as IL-4 and IL-5 in the bronchoalveolar lavage (BAL) fluid; and detection of allergen-specific IgE in the serum. The successive intraperitoneal administration of LU before the last airway OVA-challenge resulted in a significant inhibition of all asthmatic reactions. These results suggest that L undulata polyphenolic extracts possess therapeutic potential for combating bronchial asthma associated with allergic diseases. (C) 2008 Elsevier Ltd. All rights reserved.
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