期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 47, 期 8, 页码 2135-2141出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2009.05.034
关键词
Pine needle; Hydroxyl radical; Oxidative DNA damage; Oxidative cell damage; Apoptosis
资金
- Ministry of Education and Human Resources Development
- GB-Regional Innovation Research Program , Korea
- National Research Foundation of Korea [핵06B2511] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In this study, the protective effects of water extracts from pine needle (WEPN) against DNA damage and apoptosis induced by hydroxyl radical were investigated in non-cellular and cellular system. WEPN exhibited strong scavenging action on hydroxyl radical and intracellular ROS, and chelating action of Fe2+ ion. WEPN inhibited oxidative DNA damage by hydroxyl radical. Also. WEPN prevented the cells from oxidative damage through lowering p21 and BAX protein expression, blocking the cleavage of PARP and increasing Bcl-2 protein, which was confirmed by Hoechst 33342 staining. These data indicate that WEPN possesses a spectrum of antioxidant and DNA-protective properties common to cancer chemopreventive agents. (C) 2009 Elsevier Ltd. All rights reserved.
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