期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 47, 期 1, 页码 220-229出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2008.11.004
关键词
Rooibos; Honeybush; Fumonisin B-1; Cancer promotion; Rat liver
The chemoprotective properties of unfermented and fermented rooibos (Aspolathus linearis) and honeybush (Cyclopia intermedia) herbal teas, and green and black teas (Camellia sinensis) were investigated against fumonisin B-1 (FB1) promotion in rat liver utilizing diethylnitrosamine (DEN) as cancer initiator. The various teas differently affected the clinical chemical parameters associated with liver and kidney damage associated with FBI suggesting specific FB1/iron/polyphenolic interactions. Green tea enhanced (P < 0.05) the FB1-induced reduction of the oxygen radical absorbance capacity, while fermented herbal teas and unfermented honeybush significantly (P < 0.05) decreased FB1-induced lipid peroxidation in the liver. The teas exhibited varying effects on FBI-induced changes in the activities of catalase, glutathione peroxidase (GPx) glutathione reductase (GR) as well as the glutathione (GSH) status. Unfermented rooibos and honeybush significantly (P < 0.05) to marginally (P < 0.1) reduced the total number of foci (>10 mu m), respectively, while all the teas reduced the relative amount of the larger foci. Fermentation seems to reduce the protective effect of the herbal teas. Differences in the major polyphenolic components and certain FB1/polyphenolic/tissue interactions may explain the varying effects of the different teas on the oxidative parameters, hepatotoxic effects and cancer promotion in rat liver. (C) 2008 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据