期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 46, 期 3, 页码 1014-1024出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2007.10.034
关键词
chlorophyll; dibenzo[a,l]pyrene; tumor incidence; bioavailability; liver cancer; stomach cancer
资金
- NCI NIH HHS [P01 CA090890, CA 90890, P01 CA090890-04] Funding Source: Medline
- NIEHS NIH HHS [P30 ES000210-40, P30 ES003850-15, P30 ES000210, P30 ES003850, ES 00210, ES 03850] Funding Source: Medline
We recently reported that chlorophyll (Chi) strongly inhibits aflatoxin 131 preneoplasia biomarkers in rats when administered by co-gavage (Simonich et at., 2007. Natural chlorophyll inhibits aflatoxin B I-induced multi-organ carcinogenesis in the rat. Carcinogenesis 28,1294-1302.). The present study extends this by examining the effects of dietary Chi on tumor development, using rainbow trout to explore ubiquity of mechanism. Duplicate groups of 140 trout were fed diet containing 224 ppm dibenzo[a,l]pyrene (DBP) alone, or with 1000-6000 ppm Chi, for 4 weeks. DBP induced high tumor incidences in liver (51%) and stomach (56%), whereas Chi co-fed at 2000, 4000 or 6000 ppm reduced incidences in stomach (to 29%, 23% and 19%, resp., P < 0.005) and liver (to 21%, 28% and 26%, resp., P < 0.0005). Chlorophyllin (CHL) at 2000 ppm gave similar protection. Chi complexed with DBP in vitro (2Chl:DBP, K-d1 = 4.44 +/- 0.46 mu M, K-d2 = 3.30 +/- 0.18 mu M), as did CHL (K-d1= 1.38 +/- 0.32 mu M, K-d2 = 1.17 +/- 0.05 mu M), possibly explaining their ability to inhibit DBP uptake into the liver by 61-63% (P < 0.001). This is the first demonstration that dietary Chi can reduce tumorigenesis in any whole animal model, and that it may do so by a simple, species-independent mechanism. (c) 2007 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据