期刊
FOOD AND BIOPRODUCTS PROCESSING
卷 92, 期 C4, 页码 416-424出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fbp.2013.10.007
关键词
Superficial air velocity; Solid-state bioconversion; Lovastatin production; Packed bed bioreactor; Damkohler number; Aspergillus terreus
资金
- The Department of Biotechnology, Ministry of Science and Technology, Government of India [BT/PR6164/PID/06/276/2005]
The effect of superficial air velocity on lovastatin production by Aspergillus terreus PL10 using wheat bran and wheat straw was investigated in a 7 L and a 1200 L packed bed reactor. Mass transfer and reaction limitations on bioconversion in the 1200 L reactor was studied based on a central composite design of experiments constructed using the superficial air velocity and solid substrate composition as variables and lovastatin production as response. The surface response prediction showed a maximum lovastatin production of 1.86 mg g(-1) dry substrate on day 5 of the bioconversion process when the reactor was operated using 0.19 vvm airflow rate (23.37 cm min(-1) superficial air velocity) and 54% substrate composition, (w(c)). Lovastatin production did not increase significantly with superficial air velocity in the 7 L reactor. Variation in temperature and exit CO2 composition was recorded, and the Damkohler number was calculated for lovastatin production at these two scales. The results showed that in larger reactors mass transfer limitation controlled bioconversion while in smaller reactors bioconversion was controlled by reaction rate limitations. In addition, mass transfer limitations in larger reactors reduced the rate of metabolic heat removal, resulting in hot spots within the substrate bed. (C) 2013 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
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