期刊
FOOD AND AGRICULTURAL IMMUNOLOGY
卷 25, 期 2, 页码 209-219出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09540105.2013.768962
关键词
probiotic; swine; immune response; IL-10
资金
- CONACYT [83116, 1015575]
The purpose of this study was to evaluate the extent of cytokine induction and T cell proliferation in lactic acid bacteria (LAB)-stimulated porcine peripheral blood mononuclear cells (PBMCs). Porcine PBMCs were stimulated with phytohaemagglutinin (PHA) and then incubated with Bifidobacterium angulatum, Enterococcus faecalis and Lactobacillus reuteri. A decrease in the mRNA expression of interferon-gamma (IFN-) was detected; however, only a significant increase (P<0.05) in interleukin (IL)-10 expression was found in cells stimulated with E. faecalis. No changes in transforming growth factor-beta (TGF-) were observed with neither of the probiotics tested nor in T cell proliferation between LAB-stimulated and control groups. These results suggest a possible immunomodulatory probiotic effect and this effect could be due to a decrease in the inflammatory T helper 1 (Th1) immune response, and an increase of T regulatory function, as suggested by the augmented expression of IL-10.
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