期刊
FOOD AND AGRICULTURAL IMMUNOLOGY
卷 23, 期 4, 页码 352-362出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09540105.2011.634378
关键词
blueberry anthocyanidin; antioxidant activity; CC1(4)-induced liver injury; oxidation-response; human embryonic-liver cell (L-02)
This study investigated the protective effects and antioxidant mechanisms of blueberry anthocyanin extract (BBAE) in vivo and in vitro using the model of acute CC1(4)-induced liver injury in mice. It was found that BBAE significantly inhibited CC1(4)-induced liver injury and inhibited acute ethanol-induced increases in alanine aminotransferase, aspartate aminotransferase and malondialdehyde in a dose-dependent manner (P<0.05). The activities of superoxide dismutase, catalase and glycogen and glutathione reductase were markedly increased in the anthocyanin group (P<0.01). BBAE also significantly suppressed cellular injury and apoptotic cell death. In summary, BBAE possesses marked protective effects against CC14-induced liver injury, related to its ability to reduce human embryonic-liver cell (L-02) apoptosis and damage induced by oxidative stress. These findings indicate that BBAE may be of value in protecting against acute liver injury, providing pharmacological evidence supporting its clinical application.
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