4.4 Article

Effects of chitosan pentamer and chitosan hexamer in vivo and in vitro on gene expression and secretion of cytokines

期刊

FOOD AND AGRICULTURAL IMMUNOLOGY
卷 20, 期 3, 页码 269-280

出版社

TAYLOR & FRANCIS LTD
DOI: 10.1080/09540100903168157

关键词

chitosan pentamer; chitosan hexamer; cytokines; gene expression; secretion

资金

  1. National High Technology Research and Development (863) Program of China [2008AA10Z322]
  2. Shanghai Rising-Star Program [07QB14047]
  3. Shanghai-Unilever Research and Development Fund [05SU7094]
  4. National Natural Science Foundation of China [30840067]
  5. Shanghai Key Special Project of Chongming Island Ecological Construction [07DZ12043]
  6. Education Committee Foundation of Shanghai [2005DZ28]

向作者/读者索取更多资源

Effects of chitosan pentamer ((GLcN)5) and chitosan hexamer ((GLcN)6) in vivo and in vitro on gene transcription and protein translation of interleukin-1 (IL-1), tumour necrosis, factor alpha (TNF-), interleukin-2 and interferon- (IFN-) were investigated by relatively quantitative reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay. The results showed that the expression of IL-1 mRNA, TNF- mRNA, IFN- mRNA as well as the secretion of IL-1, TNF- and IFN- can both be promoted by (GLcN)6 and (GLcN)5. The promotion effects caused by (GLcN)6 were greater than that of (GLcN)5. Gene transcription and protein secretion of cytokines were promoted by (GLcN)5 and (GLcN)6 in vivo and in vitro and thus the immuno-modulating ability was promoted. This may be one of the molecular mechanisms for elucidation of immunity of chitooligosaccharides.

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