期刊
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
卷 30, 期 7, 页码 1230-1237出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/19440049.2013.800649
关键词
adulterants; herbal formulations; capillary zone electrophoresis; conductivity detection
资金
- CAPES (PROCAD) [098/2007]
- CNPq
- FAPERGS
A new method is described for the determination of the most common diuretic and laxative adulterants found in formulations of anorexics and antidepressants. The method is based on the separation of furosemide, hydrochlorothiazide, chlorthalidone and amiloride (diuretics), phenolphthalein (laxative), amfepramone (anorexic) and fluoxetine and paroxetine (antidepressants) by capillary zone electrophoresis with capacitively coupled contactless conductivity detection. The method showed a precision ranging from 1.9% to 6.9% for a concentration of 25mg/L, 0.6% to 5.3% for a concentration of 50mg/L and 1.6% to 6.0% for a concentration of 100mg/L for all analytes. The accuracy was 99% for amiloride, 102% for chlorthalidone, 101% for hydrochlorothiazide, 101% for furosemide, 94% for phenolphthalein, 105% for fluoxetine, 114% for paroxetine and 117% for amfepramone. The method allowed the drugs to be determined in the formulations at concentrations higher than 5.1mg/kg for amiloride, 7.7mg/kg for chlorthalidone, 6.8mg/kg for hydrochlorothiazide, 10.7mg/kg for furosemide, 8.4mg/kg for phenolphthalein, 11.0mg/kg for fluoxetine, 9.4mg/kg for paroxetine and 11.0mg/kg for amfepramone. Three of the 26 analysed herbal formulations were found to be adulterated (not declared on the label) with the diuretic hydrochlorothiazide. Five other samples contained diuretics declared on the label on the formulation. Thus, a total of eight samples, which were marketed as natural products, contained diuretics (declared or not) on the formulation.
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