期刊
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
卷 27, 期 8, 页码 1161-1169出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/19440049.2010.481638
关键词
high performance liquid chromatography (HPLC); liquid chromatography; mass spectrometry (LC; MS); exposure assessment; fumonisins; environmental contaminants; mycotoxins; fumonisins; Fusarium; cereals and grain; rice; cereals
资金
- National Cancer Institute [CA 94683]
- US Agency for International Development (USAID) through University of Georgia [ECG-A-00-070000100]
- NATIONAL CANCER INSTITUTE [R21CA094683] Funding Source: NIH RePORTER
Levels of serum and urinary sphinganine (Sa) and sphingosine (So), the Sa/So ratio, and urinary-free fumonisin B1 (FB1) were determined in a cross-sectional study consisting of 43 adults in Huaian and 34 adults in Fusui, China. Home-produced corn had 100% contamination with FB1. There were 93.0% (40/43) of Huaian subjects and 52.9% (18/34) of Fusui subjects with daily FB1 intakes greater than 2 mu g kg-1 body weight, which showed a significant difference (p 0.01). Levels of sphinganine and sphingosine and the Sa/So ratio were not correlated with levels of dietary exposure. The median level of the serum Sa/So ratio in Huaian subjects (0.41, range = 0.14-0.85) was significantly lower than that in Fusui subjects (0.78, range = 0.57-1.08) (p 0.01). The median level of the urinary Sa/So ratio was also significantly lower in Huaian subjects (0.31, range = 0.08-1.33) than in Fusui subjects (0.57, range = 0.03-2.52) (p 0.01). Urinary-free FB1 was detected in 83.7% (36/43) of Huaian samples and in 82.4% (28/34) of Fusui urine samples (p 0.05). However, the median level of urinary-free FB1 in Huaian subjects, 3.91 (range = 0.06-253.61) ng mg-1 creatinine, was significantly higher than 0.39 (range = 0.01-3.72) ng mg-1 creatinine found in Fusui subjects (p 0.01). These results suggest that urinary-free FB1 may be a potential biomarker for human fumonisin exposure, while further validation is needed in human epidemiological and intervention studies.
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