期刊
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
卷 27, 期 10, 页码 1405-1414出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/19440049.2010.497168
关键词
toxicology; risk assessment; method validation; metals analysis; inductively-coupled plasma (ICP); aluminium; heavy metals; vitamins; toxic elements; dietary supplements; fish and fish products; nutritional supplements
资金
- Natural Science and Engineering Research Council of Canada (NSERC)
- Alexander Graham Bell Canadian Graduate Scholarship
- Canadian Foundation for Innovation
- Ontario Innovation Trust
- Ontario government
Trace elements, most notably aluminium and strontium, have been noted for their role in the development of secondary bone disorders in haemodialysis patients. Due to the large dosages of calcium required for the maintenance of dialysis patients, this study investigated whether the source of calcium chosen for supplementation, including the form of administration (i.e. chewable forms or capsules), has an influence on the total amount of strontium and aluminium ingested daily. A convenience sample of various calcium supplement tablets and antacids was acquired, and strontium and aluminium quantification was performed by wavelength-dispersive X-ray fluorescence spectrometry. The use of readily available oyster shell-based calcium was found potentially to increase the total amount of ingested strontium substantially with concentrations reaching (2.26 +/- 0.05) (mg Sr)center dot(g Ca)-1, while the use of antacids or chewable supplements was found to contain concentrations reaching as high as (1.2 +/- 0.3) (mg Al)center dot(g Ca)-1 in the supplements analysed within this work. It is recommended that the choice of calcium supplement prescribed to individuals undergoing haemodialysis be closely regulated and noted as a possible factor in the prevalence of bone disorders reported in these patients.
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