期刊
FOLIA MICROBIOLOGICA
卷 54, 期 3, 页码 179-187出版社
SPRINGER
DOI: 10.1007/s12223-009-0028-3
关键词
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资金
- Institutional Research Concept [AV 0Z502 00510]
- Academy of Sciences of the Czech Republic [KAN 200 200 651]
- Ministry of Education, Youth and Sports of the Czech Republic [MSM 00216 20828]
- Centre of Molecular and Cellular Immunology [1M 68378 05001, MSM 00216 20858, LC 7017]
- Grant Agency of the Czech Republic [203/05/P575]
- Charles University Grant Agency [205/2004]
Geosmithia fungi are little known symbionts of bark beetles. Secondary metabolites of lilac colored species G. lavendula and other nine Geosmithia species were investigated in order to elucidate their possible role in the interactions of the fungi with environment. Hydroxylated anthraquinones (yellow, orange, and red pigments), were found to be the most abundant compounds produced into the medium during the submerged cultivation. Three main compounds were identified as 1,3,6,8-tetrahydroxyanthraquinone (1), rhodolamprometrin (1-acetyl-2,4,5,7-tetrahydroxyanthraquinone; 2), and 1-acetyl-2,4,5,7,8-pentahydroxyanthraquinone (3). Compounds 2 and 3 (representing the majority of produced metabolites) inhibited the growth of G+-bacteria Staphylococcus aureus and Bacillus subtilis with minimum inhibitory concentration of 64-512 mu g/mL. Anti-inflammatory activity detected as inhibition of cyclooxygenase-2 was found only for compound 3 at 1 and 10 mu g/mL. Compound 2 interfered with the morphology, compound 3 with cell-cycle dynamics of adherent mammalian cell lines.
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