期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 348, 期 1-2, 页码 24-34出版社
ELSEVIER
DOI: 10.1016/j.jns.2014.12.007
关键词
Ischemic stroke; Acute; Autonomic; HRV; Insula; Therapeutic
资金
- Astra Zeneca
Impaired autonomic function, characterized by a predominance of sympathetic activity, is common in patients with acute ischemic stroke. This review describes methods to measure autonomic dysfunction in stroke patients. It summarizes a potential relationship between ischemic stroke-associated autonomic dysfunction and factors that have been associated with worse outcome, including cardiac complications, blood pressure variability changes, hyperglycemia, immune depression, sleep disordered breathing, thrombotic effects, and malignant edema. Involvement of the insular cortex has been suspected to play an important role in causing sympathovagal imbalance, but its exact role and that of other brain regions remain unclear. Although sympathetic overactivity in patients with ischemic stroke appears to be a negative prognostic factor, it remains to be seen whether therapeutic strategies that reduce sympathetic activity or increase parasympathetic activity might improve outcome. (C) 2014 Elsevier B.V. All rights reserved.
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