期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 351, 期 1-2, 页码 46-51出版社
ELSEVIER
DOI: 10.1016/j.jns.2015.02.030
关键词
Feeding behaviors; GABA(A) receptor; NMDA; Orexin; Amygdala
资金
- Italian University Research Ministry (MIUR) funds
Interaction of the orexinergic (ORXergic) neuronal system with the excitatory (glutamate, L-Glu) or the inhibitory (GABA) neurosignaling complexes evokes major homeostatic physiological events. In this study, effects of the two ORXergic neuropeptides (ORX-A/B) on their receptor (ORX-2R) expression changes were correlated to feeding and grooming actions of the hibernating hamster (Mesocricetus auratus). Infusion of the central amygdala nucleus (CeA) with ORX-A caused hamsters to consume notable quantities of food, while ORX-B accounted for a moderate increase. Interestingly the latter neuropeptide was responsible for greater frequencies of grooming with respect to both controls and the hamsters treated with ORX-A. These distinct behavioral changes turned out to be even greater in the presence of L-Glu agonist (NMDA) while the alpha(1) GABA(A) receptor agonist (zolpidem, Zol) greatly reduced ORX-A-dependent feeding bouts. Moreover, ORX-A + NMDA mainly promoted greater ORX-2R expression levels with respect to ORX-A-treated hamsters while ORX-B + Zol was instead largely responsible for a down-regulatory trend. Overall, these features point to CeA ORX-2R sites as key sensory limbic elements capable of regulating eating and grooming responses, which may provide useful insights regarding the type of molecular mechanism(s) operating during feeding bouts. (C) 2015 Elsevier B.V. All rights reserved.
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