期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 359, 期 1-2, 页码 418-423出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2015.10.005
关键词
Brain frailty; Ischemic stroke; Leukoaraiosis; Old age; Outcome; Recovery; Small vessel disease
Background and aims: Ischemic stroke remains a leading cause of disability, particularly among the elderly, but this association has not been consistently noted among patients with minor stroke. We sought to determine the association of chronological age and leukoaraiosis, which is considered a marker of biological age, with the degree of neurological deficit recovery and 90-day disability after minor ischemic stroke. Methods: We retrospectively analyzed 185 patients with a minor ischemic stroke (National Institutes of Health Stroke Scale [NIHSS] score <= 5). Leukoaraiosis severity was graded according to the van Swieten scale. NIHSS was assessed at baseline, discharge, and 90-days. Multivariable linear and ordinal logistic regression analyses were constructed to identify independent predictors of the degree of NIHSS-improvement (Delta NIHSS) and 90-day outcome as assessed by the modified Rankin Scale (mRS). Results: Patients with severe leukoaraiosis had attenuated Delta NIHSS at 90 days as compared to patients with none-to-mild leukoaraiosis (p = 0.028). After adjustment, leukoaraiosis severity (p < 0.001) but not chronological age (p = 0.771) was independently associated with the Delta NIHSS by day 90. Severe leukoaraiosis (p = 0.003, OR 3.1, 95%-CI 1.5-6.4), older age (p = 0.001, OR 1.0 95%-CI 1.0-1.1), and admission NIHSS (p < 0.001, OR 1.5, 95%-CI 12-1.8) were independent predictors of the 90-day mRS. Conclusion: Leukoaraiosis is a more sensitive predictor for neurological deficit recovery after ischemic stroke than chronological age. Further study is required to establish the specific contribution of leukoaraiosis to functional outcome after minor ischemic stroke beyond its impact on recovery mechanisms. (C) 2015 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据