期刊
FITOTERAPIA
卷 130, 期 -, 页码 61-65出版社
ELSEVIER
DOI: 10.1016/j.fitote.2018.08.006
关键词
Perilla frutescens; Lamiaceae; Monoterpenoid; Anti-inflammation; RAW264.7 cell
资金
- Personalized Medicines - Molecular Signature -Based Drug Discovery and Development, Strategic Priority Research Program of Chinese Academy of Sciences, China [XDA12040315]
Perilla frutescens (L.) Britt. (Lamiaceae) is a traditionally medicinal herb in East Asian countries to treat various diseases. In present study, the low-polarity constituents of the aerial parts of P. frutescens were investigated and their anti-inflammatory effect on lipopolysaccharide (LPS)-stimulated RAW264.7 cells were assayed. Three new furanoid monoterpenoids, named as frutescenones A - C (1-3), together with thirteen known compounds (4-16) were isolated and identified on the basis of extensive spectroscopic analysis and a single-crystal X-ray diffraction study. Among these components, 1 is an unusual monoterpenoid with 2,3'-bifuran skeleton, and 3 is a rare perillaketone-adenine hybrid heterodimer, while the revised NMR arrangements of 4 were reported at the first time. Furthermore, monoterpenoid 4 and alkaloid 15 showed remarkably inhibitory effect on the production of inflammatory mediator (NO) and pro-inflammatory cytokines (TNF-alpha and/or IL-6) in LPS-stimulated RAW264.7 cells.
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