期刊
FITOTERAPIA
卷 130, 期 -, 页码 134-139出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2018.08.021
关键词
Endophytic fungus; Aspergillus sp.; Butenolides; Anti-inflammation
资金
- National Science Fund for Distinguished Young Scholars [8172500151]
- Innovative Research Groups of the National Natural Science Foundation of Cfhina [81721005]
- Program for Changjiang Scholars of Ministry of Education of the People's Republic of China [T2016088]
- National Natural Science Foundation of China [81573316, 21702067]
- China Postdoctoral Science Foundation [2017 M610479]
- Academic Frontier Youth Team of HUST
- Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College (HUST)
Terrusnolides A -D (1-4), four butenolides were isolated from an endophytic Aspergillus from Tripterygium wilfordii. The structures of 1-4 were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculation. It is interesting that 1 was a butenolide derived by a triple decarboxylation, while 2-4 were the metabolites with 4-benzyl-3-phenyl-5H-furan-2-one motif possessing an isopentene group fused to the benzene ring. In vitro anti-inflammatory effects of these isolates were evaluated in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. 1-4 exhibited excellent inhibitory effects on the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and nitric oxide (NO) in LPS-induced macrophages, comparable with the positive control (indomethacin). Those results indicated that, terrusnolides A- D might serve as new potential natural remedies for the treatment of inflammation.
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