期刊
FITOTERAPIA
卷 99, 期 -, 页码 92-98出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2014.09.008
关键词
Melia toosendan; Meliaceae; Neolignans; Lignans; Glycoside; Antioxidant activity
资金
- Key Programs of Chinese Academy of Sciences [KSZD-EW-Z-004]
- National Science & Technology Pillar Program [2011BAC09B04]
Four new neolignans, meliasendanins A-D (1-4), and a new glycoside, toosenoside A (5), together with ten known ones (6-15), were isolated from a n-BuOH partition of the fruits of Melia toosendan. Their structures were elucidated by analyses of extensive spectroscopic data and comparison of the NMR data with those reported previously. Meliasendanin A (1) was a rare neolignan containing isochroman moiety, and its absolute configuration was determined using a CD spectrum. Toosenoside A (5) was an unusual glycoside with a rare naturally occurring aglycone and its structure was confirmed by X-ray single crystal diffraction analysis. The antioxidant activity of the isolated neolignans and lignans was evaluated by ABTS radical-scavenging assay. Compounds 1 and 13 exhibited strong antioxidant activity, with IC50 values of 62.8 and 45.1 mu M, respectively. (C) 2014 Elsevier B.V. All rights reserved.
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