期刊
FITOTERAPIA
卷 97, 期 -, 页码 241-246出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2014.06.011
关键词
Endophytic fungus; Azaphilone; Meroterpenes; Cytotoxic activity
资金
- China's Marine Commonwealth Research Project [201305017]
- Special Financial Fund of Innovative Development of Marine Economic Demonstration Project [GD2012-D01-001]
- Chinese National Science Foundation [21272286]
- China Postdoctoral Science Foundation [2013M531886]
Three new metabolites (compounds 1-2 and 6), one azaphilone, and two meroterpenes, together with eleven known compounds have been isolated from a mangrove endophytic fungus, Penicillium 303#. Structure elucidation was achieved by 1D and 2D NMR spectroscopy. The absolute configurations of 1 and 2 were determined by electronic circular dichroism (ECD). Cytotoxic activities of new compounds 1-2 and 6 and compound 7were evaluated in vitro against human cancer lines MDA-MB-435, HepG2, HCT-116, and A549. Those compounds showed weak to moderate cytotoxic activities. (C) 2014 Elsevier B.V. All rights reserved.
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