期刊
FITOTERAPIA
卷 97, 期 -, 页码 211-218出版社
ELSEVIER
DOI: 10.1016/j.fitote.2014.06.013
关键词
Euphorbia stracheyi; Euphorbiaceae; Diterpenoid; Sesquiterpene; Cytotoxicity
资金
- National Natural Science Foundation of China [31300293, 81202584]
- Applied Foundation Research, Yunnan Province [2013FB067]
- Basic Research Project of Ministry of Science and Technology of China [2012FY110300]
- Major State Basic Research Development Program [2010CB951704]
Three new diterpenoids, stracheyioids A-C (1-3), as well as 36 known compounds (4-39) were isolated from the whole plants of Euphorbia stracheyi. Compound 1 was a rare 13-deoxy tigliane diterpenoid and compound 2 was an ingenol diterpenoid characterized by an unique 2Z,4Z-decadienoyl acidic moieties. All the known compounds were isolated from E. stracheyi for the first time. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 1-39 were tested for their cytotoxicity against five cancer cell lines (A-549, MCF-7, Hep G2, Hela and P388) and showed IC50 values in the range 6.64-42.86 mu M. The antiangiogenic activities of the isolated compounds were also evaluated using a zebrafish model. (C) 2014 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据