期刊
FITOTERAPIA
卷 90, 期 -, 页码 192-198出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2013.07.019
关键词
Melia toosendan; Meliaceae; Limonoid; Nimbolinin; Neurite outgrowth-promoting activity
资金
- Natural Science Foundation for Young Scientists of Shanxi Province, China [2011021007-3]
- Science and Technology Innovation Foundation of Shanxi Medical University [C01201008]
- Youth Foundation of Shanxi Medical University [02200917]
- Start-up Foundation for Doctors of Shanxi Medical University [03200812]
- Program for the Top Science and Technology Innovation Teams of Higher Learning Institutions of Shanxi Province
Four new limonoids (1-4), together with five known limonoids (5-9), were isolated from the fruits of Melia toosendan. Their structures were elucidated based on extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, IR, [alpha](D)). The isolated compounds were evaluated for their neurite outgrowth-promoting activities. Compounds 2 and 6 significantly enhanced NGF-mediated neurite outgrowth in PC12 cells at concentrations ranging from 0.1 to 50.0 mu M. (C) 2013 Elsevier B.V. All rights reserved.
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