期刊
FITOTERAPIA
卷 85, 期 -, 页码 64-68出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2012.12.030
关键词
Aphanamixis grandifolia; Meliaceae; Cycloartane triterpenoids; Antibacterial activities
资金
- National Basic Research Program of China (973 Program) [2009CB522300, 2009CB940900]
- National Natural Science Funding of China [31170332]
- Young Academic and Technical Leader Raising Foundation of Yunnan Province [2010CI047]
Three new cycloartane triterpenoids, aphagrandinoids A-C (1-3), and a new natural product, aphagrandinoid D (4), together with a known compound, were isolated from the leaves and twigs of Aphanamixis grandifolia. Their structures were elucidated by extensive NMR and MS techniques. Aphagrandinoid A (1), a 29-nor-cycloart triterpenoid, features with a sprio ring system at the side chain, while aphagrandinoid C (3) is a pentnortriterpenoid. Antibacterial activities of these five compounds were also evaluated. Compounds 1 and 5 showed weak antibacterial activities (MIC values: 1.57-3.13 mu g/mL) against Staphylococcus aureus, MRSA 92(#), and MRSA 98(#). (C) 2013 Elsevier B.V. All rights reserved.
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