期刊
FITOTERAPIA
卷 91, 期 -, 页码 15-20出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2013.08.014
关键词
Green alga; Caulerpa racemosa; Bisindole alkaloids; Racemosins A and B; Neuro-protective activity
资金
- National Natural Science Foundation of China [20862013, 81001397, 21162016, 81273430]
- National Marine 863 Project [SS2013AA090202]
- Natural Science Foundation of Jiangxi Province, China [2010GQY0217, 20114BAB205034]
Racemosin A (1), a structurally unique bisindole alkaloid possessing the seco-indolo[3,2-a] carbazole skeleton with two uncommon indolinenone units both conjugated with a methyl propenoate moiety, and its unusual cyclized derivative, racemosin B (2), were isolated from the green alga Caulerpa racemosa, together with the most commonly encountered pigment in the genus Caulerpa, caulerpin (3). Their structures were elucidated by extensive spectroscopic analysis and by comparison with data for related known compounds. A plausible biosynthetic pathway of 1 and 2 was proposed. In a neuro-protective assay, compound 1 significantly attenuated the A beta(25-35)-induced SH-SY5Y cell damage with a 14.6% increase in cell viability at the concentration of 10 mu M when compared to epigallocatechin gallate (EGCG, 16.57% increase at 10 mu M) as the positive control. (C) 2013 Elsevier B.V. All rights reserved.
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