期刊
FITOTERAPIA
卷 84, 期 -, 页码 40-46出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2012.09.026
关键词
Inula japonica Thunb.; Dimeric sesquiterpene lactones; Biosynthesis; Inhibitory effects of nitric oxide production
资金
- NSFC [30725045, 81102778]
- Global Research Network for Medicinal Plants (GRNMP)
- King Saud University, Shanghai Leading Academic Discipline Project [B906]
- FP7-PEOPLE-IRSES (TCMCANCER Project) [230232]
- Key Laboratory of Drug Research for Special Environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products [10DZ2251300]
- Scientific Foundation of Shanghai China [09DZ1972200, 09DZ1975700, 09DZ1971500, 10DZ1971700]
- NCET Foundation
Four new dimeric sesquiterpene lactones (japonicones Q-T, 1-4) were isolated from the aerial part of Inula japonica Thunb., together with two known ones. Their structures were determined mainly by 1D and 2D NMR spectroscopic techniques including HSQC, H-1-H COSY, HMBC, and NOESY. Herein, the inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages of 1-6 were evaluated; IC50 values were tested as 8.5, 8.9, 4.3, 4.3, 4.2, and 9.2 mu M, respectively. (c) 2012 Elsevier B.V. All rights reserved.
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