期刊
FITOTERAPIA
卷 89, 期 -, 页码 218-223出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2013.05.022
关键词
3, 4-seco-Labdane diterpenoids; Callicarpa nudiflora; Nitric oxide; RAW 264.7
资金
- National Natural Science Foundation [81060367]
- National Key Technology RD Program [2012BAI30B02]
As a part of our ongoing search for bioactive compounds from the leaves of Callicarpa nudiflora that inhibit nitric oxide (NO) production, the 90% EtOH fraction eluted by macroporous resin adsorption was found to show significant inhibitory activity against the production of NO in RAW 264.7 stimulated by lipopolysaccharide (U'S). Bioactivity-guided isolation of the fraction yielded three new bioactive diterpenoids, named ent-3, 4-seco-14-carbonyl-15, 16-epoxy-4(18), 8(17), 13(14)-labdatrien-3-oic acid (1), syn-3, 4-seco-12R-hydroxy-15, 16-epoxy-4(18), 8(17), 13(16), 14(15)-labdatetraen-3-oic acid (2) and syn-3, 4-seco-12S-hydroxy-15, 16-epoxy-4(18), 8(17), 13(16), 14(15)-labdatetraen-3-oic acid (3). Their structures and configurations were elucidated by comprehensive spectroscopic analysis. All the three compounds exhibited potent inhibitory activity on NO production in LPS-activated RAW 264.7 macrophage cells. (C) 2013 Elsevier B.V. All rights reserved.
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