期刊
FITOTERAPIA
卷 86, 期 -, 页码 29-34出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2013.01.015
关键词
Alpinia japonica; Zingiberaceae; Sesquiterpene; Nitric oxide
资金
- National Natural Science Foundation of China [21072230]
- Natural Science Foundation of Jiangsu Province, China [BK2008039]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
A novel norsesquiterpene (1), three new bisabolenes sesquiterpenes (2-4), along with 7 known compounds (5-11), were isolated from the rhizomes of Alpinia japonica. The structures of the new compounds were elucidated by analysis of spectroscopic data. The absolute configuration of C-1 in 3 was deduced via the circular dichroism data of the in situ formed [Rh-2(OCOCF3)(4)] complexes. Inhibitory effects of the isolates on nitric oxide production in lipopolysaccaride-activated RAW264.7 macrophages were evaluated. Compound 6 showed significant inhibitory activity with IC50 value of 53 mu M, and compounds I, 3, 5 and 7-10 exhibited moderate inhibitory activities with IC50 values between 24.5 and 46.3 mu M. (C) 2013 Elsevier B.V. All rights reserved.
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