4.6 Article

Nerium oleander derived cardiac glycoside oleandrin is a novel inhibitor of HIV infectivity

期刊

FITOTERAPIA
卷 84, 期 -, 页码 32-39

出版社

ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2012.10.017

关键词

Oleandrin; Envelope protein; Cardioglycoside; Nerium oleander; HIV inhibitors

资金

  1. Nerium Biotechnology, Inc. (San Antonio, TX)

向作者/读者索取更多资源

We evaluated the effectiveness of Anvirzel (TM), an aqueous extract of Nerium oleander on HIV infection of human peripheral blood mononuclear cells. Oleandrin, the principle cardiac glycoside (CG) in Anvirzel (TM) has been shown to exhibit anti-cancer properties but its efficacy against HIV is unknown. Treatment with AnvirzelTm significantly reduced the infectivity of virus produced from infected cells without any change in the total amount of virus produced. This is in contrast to treatment with AZT, a potent inhibitor of HIV replication that has been shown to significantly reduce virus production. Relative to untreated cultures, virus in cultures treated with oleandrin had significantly reduced expression of the envelope protein gp120, the sole determinant of virus infectivity, suggesting a novel mechanism underlying the impaired infectivity. These results support the potential utility of the Nerium oleander aqueous extract, containing the CG oleandrin as a novel candidate anti-HIV therapeutic. (c) 2012 Elsevier B.V. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据