期刊
FITOTERAPIA
卷 83, 期 4, 页码 765-769出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2012.03.007
关键词
Catharanthus roseus; Apocynaceae; Dimeric indole alkaloid; Circular dichroism; Cytotoxicity
资金
- National Natural Science Foundation of China [U0932004, 30901848, 81001374, 90913020]
- Natural Science Foundation of Guangdong Province [8351063201000003]
Three new dimeric indole alkaloids (1-3), together with five known ones (4-8), were isolated from the whole plants of Catharanthus roseus. The structures and absolute configurations of new compounds were elucidated by means of NMR and CD analyses. All these compounds were evaluated for their in vitro cytotoxic activities against human breast cancer cell line MDA-MB-231. (C) 2012 Elsevier B.V. All rights reserved.
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