期刊
FITOTERAPIA
卷 83, 期 5, 页码 843-848出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2012.03.004
关键词
Dipsacus asper; Triterpene saponin; Asperosaponin A-C; Amyloid beta; Cytotoxic activity
资金
- National Natural Science Foundation of China [30730113]
Three new triterpene saponins, named asperosaponin A-C (1-3), together with seven known triterpene saponins (4-10) were isolated from the roots of Dipsacus asper. The structures of compounds 1-3 were elucidated on the basis of detailed spectroscopic analysis and chemical methods. Compounds 1-3, 6-10 had significantly protective effects in PC12 cells against the A beta(25-35) induced cytotoxicity. All the compounds isolated showed no cytotoxic activity against three human cancer cell lines, A-549, Bel-7402 and BGC-823. (C) 2012 Elsevier B.V. All rights reserved.
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