期刊
FITOTERAPIA
卷 82, 期 1, 页码 38-43出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2010.09.004
关键词
Ginger; Zingiber officinale; Cyclooxygenase; Gingerol; Shogaol; Paradol
资金
- National Cancer Institute [P01 CA48112]
- Office of Dietary Supplements [P50 AT00155]
- National Center for Complementary and Alternative Medicine
- Office on Research in Women's Health
- NATIONAL CANCER INSTITUTE [P01CA048112] Funding Source: NIH RePORTER
- National Center for Complementary & Integrative Health [P50AT000155] Funding Source: NIH RePORTER
Ginger roots have been used to treat inflammation and have been reported to inhibit cyclooxygenase (COX). Ultrafiltration liquid chromatography mass spectrometry was used to screen a chloroform partition of a methanol extract of ginger roots for COX-2 ligands, and 10-gingerol, 12-gingerol, 8-shogaol, 10-shogaol, 6-gingerdione, 8-gingerdione, 10-gingerdione, 6-dehydro-10-gingerol, 6-paradol, and 8-paradol bound to the enzyme active site. Purified 10-gingerol, 8-shogaol and 10-shogaol inhibited COX-2 with IC(50) values of 32 mu M, 17.5 mu M and 7.5 mu M, respectively. No inhibition of COX-1 was detected. Therefore, 10-gingerol, 8-shogaol and 10-shogaol inhibit COX-2 but not COX-1, which can explain, in part, the anti-inflammatory properties of ginger. (C) 2010 Elsevier B.V. All rights reserved.
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