Hypoglycemic effect of lupin seed γ-conglutin in experimental animals and healthy human subjects

A lupin seed gamma-conglutin-enriched preparation was tested in a glucose overload trial with both murine models and adult healthy volunteers. The results with rats showed a dose-dependent significant decrease of blood glucose concentration, which confirmed previous findings obtained with the purified protein. Moreover, three test-product doses equivalent to 630, 315. and 157.5 mg gamma-conglutin, orally administered 30 min before the carbohydrate supply, showed a relevant hypoglycemic effect in human trials. Insulin concentrations were not significantly affected. The general hematic parameters did not change at all. This is the first report on the glucose-lowering effect of lupin gamma-conglutin in human subjects. (C) 2011 Elsevier B.V. All rights reserved.